Catalog
Episodes
Episode 620 - Marc TheobaldOct 25, 2026 · 1 hr 17 minComedian Marc Theobald (@comedyfamilyman) joins Jesse, Andy and Matt to talk about Jesse's new place, working with Tracy Morgan, manifesting, Marc's phamaceutical sales background, how honey bee stingers pump venom, what happens to bees after they sting and light-activated tattoo technology.- Episode 619 - Sarah MorganOct 15, 2026 · 1 hr 5 minWriter/performer Sarah Morgan (@slmorgo) returns to the show to talk with Andy and Matt about her new horror short film Blood & Chocolate, the importance of Neil Armstrong's moon poop, Venus eating its own moon and the rainbow that was left out of The Odyssey.
- Episode 618 - Ola DadaSep 30, 2026 · 1 hr 11 minComedian Ola Dada (@showtime.dada) joins Andy, Jesse and Matt to talk about moving from Nigeria to Canada, summer nights in Alberta, Africa breaking apart faster than we thought, the true size of Africa, map projection pros and cons, the work of James McAvoy and how light during sleep can hurt your heart.
- Episode 617 - Paul JaySep 15, 2026 · 1 hr 23 minComedian Paul Jay (@pauljaycomic) returns to the show after a 14-year hiatus to talk with Jesse and Andy about the comedy message board A Special Thing, the genius of Randy Feltface, Bobby Fingers' Depp Diorama, the surprising way that cuttlefish see color, tetrachromacy, The Baby, The Immigrant and The Guy On Mushrooms, and building a Martian home out of yeast and gelatin.
- Episode 616 - Katie Novotny returnsSep 10, 2026 · 1 hr 15 minWe took full advantage of our friend Katie Novotny (@katienovotnyyyyy) stuck at home recovering from surgery to get her back on the show! Her special Son of Your Dreams is free to stream on YouTube right now!
We talk about a supersonic trebuchet! A new fecal transplant story, this time for food allergies! And also if your microbiome's linked to psychopathy! Plus massively long-lived sturgeon! How other sturgeon get it on! Musician Slash getting his own snake species! How the number of species is calculated, with a bit of help from our buddy Matt Parker! And fake mermaid science!
In the Patreon bonus, there's some scientific proof of cats being dicks.
- Episode 615 with Luca Ferro!Sep 5, 2026 · 1 hr 10 minChicago/NY comedian Luca Ferro (@lucaferrocomedian) joins the gang to talk about Dolphins using tools! And having names! Plus monkeys falling for (and "falling for") Monkey AI!
Plus in the Patreon bonus ep we find out about a newcomer to the carnivorous plant club.
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- Episode 614 - Jon BennettAug 25, 2026 · 57 minComedian Jon Bennett (@jonbennettcomedy) joins Matt and Jesse to talk about how deep breaths can actually increase risk-taking behavior, the air on Titan being thick enough that humans could fly with strap-on wings, a bizarre new material discovered in Hiroshima bombing debris. and Jon's one-man show American't playing in Toronto through August 31st.
- Episode 613 - Dave HolmesAug 8, 2026 · 1 hr 18 minWriter/podcaster/host Dave Holmes (@daveholmes) returns to the show to talk with Jesse, Matt and Andy about his new Substack Cocksure, his memoir Party of One, the waning days of monoculture at MTV, Dave's excellent MTV history podcast Who Killed The Video Star?, Helen Twelvetrees, the band Rocket, Dan Taberski's Manifesto podcast, blocking out your inner cynical friend, the movie Ghost Dad, Dave's other excellent podcast Waiting For Impact, why cannibalism keeps popping up in human civilization, BALLS on the moon, volunteering for space mission simulations and how a heatwave revealed lost archaeological sites in Wales.
- Episode 612 - Alison LeibyJul 26, 2026 · 1 hr 9 minComedian/writer Alison Leiby (@alisonleiby) joins Jesse, Andy and Matt to talk about her new memoir I'm A Lot, AI promotional scams, chronic back pain, how happiness can literally break your heart, takotsubo octopus traps, a breatkthrough in Alzheimer's-related sleep loss, plaque talk, inhaling CO2 to help with Alzheimer's, debunking the electric pangolin, giraffe math and ranking the intelligence of animals and demons.
- Episode 611 with Hannah RoeschleinJul 16, 2026 · 57 minHannah Roeschlein (@handerpumprules) joins Jesse and Matt for half the episode before the computer gods get angry, forcing the two guys to finish the show solo. But between us we talk about Filipino divers! Synthetic cells! And Hobbits and Komodo dragons!
In the Patreon bonus, we get into space fires, and hear how Matt got served by a legendary astronaut and Jesse angered BBQ fans.
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- Episode 610 - Kirk SmithJul 6, 2026 · 1 hr 13 minComedian Kirk Smith (@kirksmithcomedy) joins Jesse, Andy and Matt to talk about his books Rice Krispies with Ketchup and Movin, pools and jacuzzis, competitive eating champions, the science of fireworks, the lack of rap in the Billboard Hot 100 and Andy's upcoming Oregon tour.
- Episode 609 - Ryan ConnerJun 26, 2026 · 1 hr 17 minComedian/author Ryan Conner (@ryanconnercomedy) returns to the show to talk with Jesse, Andy and Matt about his new memoir 12 Guys Walk Into a Kitchen, Vietnamese refugees, Tippi Hedren's nail salon legacy, British soccer fans cleaning up in the US, the worst year to be alive, 2020 vs. 1968, hipster nostalgia, stomp clap tall bikes and nuclear (not atomic) clocks.
- Episode 608 - Laura Sams JordanJun 18, 2026 · 1 hr 16 minZoologist/producer/composer/podcaster Laura Sams (@lauramsams) Jordan joins Jesse, Matt and Andy to talk about fliming grizzly bears in Alaska, studying hyenas in Africa, Laura's kid-friendly wildlife podcast The Happiest Animal Show, starting a production company with your sibling, interviewing six-year-olds, Laura's inflatable basking shark, the shocking actual appearance of basking sharks, the Horniman walrus, they're all in my Wildlife Treasury, a duck in a jersey and inserting a human language gene into mice.
- Episode 607 - Diana HongJun 4, 2026 · 1 hr 12 minComedian Diana Hong (@dhongcomedy) joins Jesse, Andy and Matt to discuss cat ownership, Shadow Force, Sawbones and the McElroy-iverse, Diana's golf career, outsider commemorative art, a new way to get your lithium, battery types, alkali metals reacting with water, Lithium Valley, bottle recycling in the US, Sonny Bono's Palm Springs legacy, awful bronze statues, RIP Primm (maybe), an optimal robot body with 20 legs and Old Glory Robot Insurance.
- Episode 606 - Charles StarMay 29, 2026 · 1 hr 6 minLawyer-turned-comedian and self-professed podcast slut Charles Star (@ugarles) returns to the show to talk about his podcast No Homework, celebrity roasts, Wings album covers, bad abbreviations, contact lenses that ease depression in mice, the insect with the biggest nuts, self-recognition in beluga whales and the link between sleep duration and accelerated aging.
- Episode 605 - James FreyMay 18, 2026 · 1 hr 2 minComedian and former paramedic James Frey (@jamesfreycomedy) joins Andy, Jesse and Matt to talk about firefighter dreams and emergency medicine reality, James' Ventura comedy show, giving CPR in civilian life, a woman (well, women) who couldn't burp, getting fobbed off, sucker fish hiding in manta rays' butts, a quantum battery breakthrough and missing scientist conspiracy theories.
- Episode 604 - Shane MaussMay 11, 2026 · 1 hr 12 minComedian Shane Mauss (@shane_mauss) returns to the show to talk about his upcoming comedy special TRIPS: The First Dose, how LSD affects blind people, misophonia's link to anxiety and depression, the goring of a matador's ass, plants 'hearing' rain coming and Shane's comedy/science podcast Here We Are.
- Episode 603 - Brandie PoseyMay 3, 2026 · 1 hr 17 minComedian Brandie Posey (@brandazzle) returns to the show to talk with Jesse, Andy and Matt about the geography of Jersey, Brandie's label Burn This Records and her new comedy special Milk Job, Andy's other ska band, why humans can't regenerate limbs, a huge volcano refilling with magma, the dude who got both his arms reattached in 1992, whether Yellowstone is due for an eruption and Fruit Love Island.
- Episode 602 - Chandler DeanApr 25, 2026 · 1 hr 16 minComedian/speechwriter Chandler Dean (@chandlerjdean) joins Jesse, Andy and Matt to talk about his show Abolish Everything!, Jesse's over-the-top stuffed animal purchase, poop speed as a health indicator, the Bristol Stool Chart, medical fake poo, Jesse's obsessions with fake foods, giant stuff and really tiny stuff, Artemis II's avatar crewmates, the magic of Tiny Empath Babies, videos of Tiny Empath Babies and more videos of Tiny Empath Babies.
- Episode 601 - Amber PrestonApr 17, 2026 · 1 hr 15 minComedian Amber Preston (@prestonparty) returns to help Andy, Jesse and Matt celebrate the big six-oh-one and talk about Artemis II, frozen urine in space, a microbe that makes you stronger, Trump's insane handshakes, sharks testing positive for cocaine and sperm difficulties in zero-g.
- Episode 600 - Katie NovotnyApr 6, 2026 · 1 hr 9 minComedian Katie Novotny (@katienovotnyyyyy) joins Matt and Andy to discuss her special Son of Your Dreams, whale junk, headbutting whales, the 20-year cycle of fashion, an evolved arsenic tolerance, Thai children who can see underwater and a Warsaw Poland Bros. song Andy plays on.
- Episode 599 - Monica NeviMar 29, 2026 · 1 hr 3 minComedian Monica Nevi (@monicanevi) joins Andy, Jesse and Matt to talk about her special Big Stepdad Energy, what VO2 max means, esports scholarships, vasectomy rate spikes during March Madness, the effect of carbonated water on gamer performance, a bunch of human brain cells in a petri dish playing Doom, unlocking the antibacterial secrets of frogs and using frogs to keep milk from spoiling.
- Episode 598 - Matthew CoeMar 19, 2026 · 1 hr 12 minComedian Matthew Coe (@matthew_coe__) joins Jesse, Andy and Matt to talk about parents watching comedy, Matthew's show My Therapist Knows Your Name, Matthew's hypoplastic right heart syndrome, the closing of the foramen ovale, a Japanese study of falling cats, a robot handling potato chips, and an averted Moon asteroid close call.
- Episode 597 - Jackie KashianMar 5, 2026 · 1 hr 5 minComedian Jackie Kashian (@jackiekashian) returns to the show to talk with Jesse and Matt about her new standup special Alter-Kashian, huge amounts of hydrogen inside the Earth's core, weird things yawning does in your brain and a possible universal vaccine. See Matt on tour in Seattle and Portland, and Andy on tour in Santa Barbara.
- Episode 596 - Forrest ShawFeb 26, 2026 · 1 hr 16 minComedian and former marine biologist Forrest Shaw (@forrestshaw) returns to the show to talk with Matt, Andy and Jesse about his new live show The Ocean Hates You, his addiction podcast I've Got A Problem, bonnethead sharks, the rise of online sports gambling, a Kalshi market about aliens, and the myth of alpha wolves.
- Episode 595 - Aisha AlfaFeb 17, 2026 · 1 hr 5 minComedian Aisha Alfa (@aishaalfa) joins Jesse, Andy and Matt to talk about comedy in Winnipeg, Jesse's Megyn Kelly-loved Olympics tweet, the cult movie Phantom of the Paradise, Andy's family friend Olympic ice dancer, the German word for a living stork with an arrow in it, the penis injection Olympic ski jumping controversy, an amazing artificial lung feat, Jesse's artificial lung cat bed, Aisha's newsletter and Andy's upcoming ska shows.
- Episode 594 - David HuntsbergerFeb 4, 2026 · 1 hr 8 minComedian David Huntsberger returns to the show to talk with Matt, Jesse and Andy about his podcast Intercepts, his new platform The Endless Abyss, the lost art of sketch comedy albums, the world's worst redaction, Redactle, how dogs build their vocabularies like toddlers, Stella the talking dog, dumb dogs, breed stereotypes, Bad Will Hunting, the worst logo and name in education, longevity in meat-eaters and the foresight of The Machine Stops.
- Episode 593 - Diya BasraiJan 30, 2026 · 1 hr 10 minComedian/neuroscientist Diya Basrai (@diyabasrai) joins Jesse, Andy and Matt to talk about Moravec's Paradox, whether there's something meat-specific about intelligence, a less-pessimistic AI take, a tool-using cow, Diya's comedy special and his comedy/science live show Uncontrolled Variables.
- Episode 592 - Jon StringerJan 21, 2026 · 1 hr 10 minComedian Jon Stringer (@jonjstringer) joins Andy, Jesse and Matt to talk about living in a converted rural Kansas church, the intricacies of comedy competitions and cruise ship comedy, dry ice PVC soupcan launchers, the oldest known use of poison arrows, retail blowguns and their misuse, vibe-coding a band manager, why you should stop using hydrogen peroxide on cuts, sword canes and pendulous doorknockers.
- Episode 591 - Imaan HadchitiJan 13, 2026 · 1 hr 14 minComedian Imaan Hadchiti (@imaanfrankhadchiti) joins Jesse, Andy and Matt to talk about Rima syndrome, the movie Tiptoes, the passing of an art legend, sniffing farts to prevent Alzheimer's, what actually causes ice to be slippery, when physical aging really kicks in and making paralyzed rats walk again in a really creepy way.
- Episode 590 - Waen ShepherdJan 4, 2026 · 1 hr 12 minComedian/actor/writer/composer Waen Shepherd (@waenshep) joins Andy, Jesse and Matt to talk about the new album from his alter ego Gary Le Strange, the biology of elves, the best chocolate chip cookie recipe, a runaway supermassive black hole, a lemon-shaped exoplanet and the music of Gary Wilson.
- Episode 589 - Chris DuffyDec 28, 2025 · 1 hr 10 minComedian/host/author Chris Duffy (@chrisiduffy) returns to the show to talk with Jesse, Andy and Matt about his new book Humor Me: How Laughing More Can Make You Present, Creative, Connected, and Happy, his radio show/podcast You're The Expert, his TED podcast How To Be a Better Human, the unintentionally phallic Covid-era Terry Crews video Chris worked on with Matt and Andy, prescribing standup to improve mental health, training Swedish crows to pick up cigarette butts and a frozen worm revived after 46,000 years.
- Episode 588 - Buddy FitzpatrickDec 16, 2025 · 1 hr 17 minComedian Buddy Fitzpatrick (@buddycomic) joins Andy, Matt and Jesse to talk about Batman's effect on subway chivalry, the rooms of Madonna Inn, ladyfingers, manmade fire from 350,000 years earlier than previously thought, monogamy across the animal kingdom and an insane chain of rabies transmission via organ transplantation.
- Episode 587 - Adam BurkeDec 9, 2025 · 1 hr 23 minComedian Adam Burke (@atpburke) joins Andy, Jesse and Matt to talk about Adam's new comedy special Unamerican, debunking the Stanford Prison Experiment, classic '80s Arnold movies, Matt and Jesse performing together in Nashville, the preacher who shot an escaped lab monkey, AIs that believe themselves to be more rational than humans, 3D printing with a mosquito proboscis, Andy's upcoming orchestra shows and Matt's upcoming San Deigo standup show.
- Episode 586 - Ophira EisenbergNov 28, 2025 · 1 hr 24 minComedian/writer/NPR host Ophira Eisenberg (@ophirae) joins Andy, Jesse and Matt to talk about her podcast Parenting Is a Joke, her upcoming special produced by Lewis Black, the effect of venting on anger, a rage room show Andy worked on, why you should leave uncontacted tribes alone, the wombat-thief influencer and why you should speak up to seagulls.
- Episode 585 - Jeff ZenisekNov 14, 2025 · 1 hr 12 minComedian Jess Zenisek (@jeffzenisek) joins Andy, Jesse and Matt to talk about tennis, homophobic sports stereotypes, Jesse's new ski persona, Mr. Wizard, Jeff's hair care regimen, a tiny tyrannosaur, a better rock-paper-scissors strategy, gray hair's relationship to cancer, the worst music to play during sex and the banger Parked By The Lake.
- Episode 584 - Drew DroegeNov 10, 2025 · 51 minComedian/playwright Drew Droege (@drew_droege) joins Matt, Jesse and Andy to talk about his new off-Broadway play Messy White Gays, X-ray NBA poker fraud and why birds sing after a solar eclipse.
- Episode 583 - Mehran KhaghaniOct 29, 2025 · 53 minWonderful NY comic Mehran Khagani (@themehran) joins Jesse and Matt to talk about escaping from Iran, working at the Harvard School of Public Health, hyrax butt drag fossil marks, Canadian heart transplants and the most pristine star in the universe!
In the patreon bonus we get into penguin micronaps.
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- Episode 582 - Jen KoberOct 20, 2025 · 1 hr 11 minComedian/actor Jen Kober (@jenkober) joins Andy, Jesse and Matt to talk about comedy in Louisiana, Oktoberfest, buxom wenches, the connection between fish buttholes and fingers, a koala chlamydia vaccine, Jesse's newfound raccoon fame, light-powered gears that fit inside a strand of hair and Jen's membership in the Star Wars canon.
- Episode 581 - NASA Exoplanet Science Ambassador Anjali TripathiOct 5, 2025 · 1 hr 20 minNASA astrophysicist and JPL Exoplanet Science Ambassador Anjali Tripathi joins Andy, Jesse and Matt to talk about exoplanets and the different ways of finding them including radial velocity, transits and gravitational microlensing, the challenges of studying planetary atmospheres, why telescopes are built in deserts or in space, Anjali's time at the White House Office of Science and Technology Policy, science communication projects like the Logic 44ever rap video, the upcoming Nancy Grace Roman Space Telescope, dark matter, lasers in astronomy, Halloween at the White House, the odd "smells" of other planets and how to take a virtual tour of JPL.
- Episode 580 - Michelle MurphySep 27, 2025 · 1 hr 21 minComedian Michelle Murphy (@meeshoffleash) joins Andy, Matt and Jesse to talk about playing tennis for Grinnell, the Enhanced Games, celebrities trying their hands at winter sports, Jesse's accidental mermaid book purchase and the Dr. Seuss book he was aiming for, Burning Man missionaries, LSD to fight anxiety and surprisingly not too uncommon iridescent mammals.
- Episode 579 - Ken ReidSep 17, 2025 · 1 hr 15 minComedian Ken Reid (@kennethwreid) joins Jesse, Matt and Andy to talk about growing up a child of television, mud wrestling, Ken's podcast TV Guidance Counselor, an HIV prevention breakthrough, the insanity of Movie 43, the human washing machine no one asked for, blasting plastic waste with a plasma torch, Doja Cat's nod to Max Headroom, Ladies and Gentlemen, The Fabulous Stains, the reason plastic recycling mostly ended, Andy's Oktoberfest shows in Lake Arrowhead and John Williams polka music.
- Episode 578 - Ryan O'FlanaganSep 9, 2025 · 1 hr 11 minComedian Ryan O'Flanagan (@ryanoflan) joins Matt, Jesse and Andy to talk about Ryan and Andy's chance encounter in a bar in Leadville, Married With Children tattoos, neanderthals and homo sapiens interbreeding, a novel telescope shape to help search for exoplanets, an insane impression of a neanderthal voice and Ryan's podcast Laser Show.
- Episode 577 - Myq KaplanAug 29, 2025 · 1 hr 11 minComedian Myq Kaplan (@myqkaplan) returns to the show to talk to Andy, Jesse and Matt about growing out his eyebrows during the pandemic, babies distinguishing Ps from Bs, linguistics, sign language variations, standups aping Shane Gillis, the Mr. Beast voice, birds' preference for crapping in the air, strong link versus weak link problems, Ryan North, whether you should pay for bad art, what sequels always get wrong and Myq's great Substack.
- Episode 576 with Macey Isaacs!Aug 20, 2025 · 1 hr 1 minComedian and host of the SSRI'M OK podcast Macey Isaacs joins the gang to talk about a meteorite that's older than our planet! AI and attachment theory! And some more AI nonsense before Andy's connection quit in a fury!
In the Patreon bonus we find out why living near the ocean extends your life.
Follow Macey on instagram and check out her podcast, and her Don't Tell special when it drops!
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- Episode 575 - Matt ParkerAug 11, 2025 · 1 hr 6 minComedian/mathematician/YouTuber/author Matt Parker (@standupmaths) joins Jesse, Andy and Matt to talk about his new book Love Triangle: How Trigonometry Shapes the World, his podcast A Problem Squared, his Edinburgh Fringe show Getting Triggy With It, Mathstodon, a hawk that uses traffic patterns to target prey, desire paths, Earth's leaking core, the Gibeon meteor, Matt's comedy tour dates and Andy's Colorado music dates.
- Episode 574 - Josh GondelmanAug 1, 2025 · 59 minComedian Josh Gondelman (@joshgondelman) joins Andy and Matt to talk about his new special Positive Reinforcement, his newsletter, his wife Maris Kreizman's new book of essays, the geek/nerd/dweeb/dork Venn diagram, Nancy Kerrigan and Chris Farley, a new ass-grass fad among chimps, ass/gas/grass bumper stickers, neanderthals eating maggots and rotten meat, how surprisingly warm Uranus is and Tylenol inducing risky behavior.
- Episode 573 - Kai HumphriesJul 25, 2025 · 1 hr 9 minComedian Kai Humphries (@kaihumphries) joins Matt, Andy and Jesse to talk about his new special Gallivanting, the passing of Hulk Hogan, superheating solid gold, the Air Bud cinematic universe and an enormous 80,000-year-old blob in Utah.
- Episode 572 - Eric RochaJul 22, 2025 · 1 hr 11 minComedian Eric Rocha (@ericrochacomedy) joins Andy, Jesse and Matt to talk about competing namesakes, fezzes, last suppers, Jesse's macronutrient gas, sleep hygiene, comedy on airplanes, what would happen if you threw a paper airplane from the ISS, a neanderthal fat factory, Matt's standup tour and Andy's Colorado ska tour.
- Episode 571 - Bryan CookJul 12, 2025 · 1 hr 3 minComedian and Jimmy Kimmel Live! writer Bryan Cook (@bryancooking) returns to the show for a technical difficulty-laden episode in which Jesse and Andy talk with Matt while he's on a cruise ship, covering topics including comedy on a boat, candlepin bowling, a new interstellar object, crypto failures, Anthropic's Claude having an identity crisis, the Sean Connery classic Zardoz, an AI band with way too many Spotify plays, Matt's upcoming standup shows and Andy's upcoming Colorado tour with Warsaw Poland Brothers.
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